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Monday, July 27, 2020 | History

2 edition of Novel steroidal metal complexes with potential pharmaceutical applications found in the catalog.

Novel steroidal metal complexes with potential pharmaceutical applications

Wai-Han Cheung

Novel steroidal metal complexes with potential pharmaceutical applications

by Wai-Han Cheung

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  • 20 Currently reading

Published .
Written in English


Edition Notes

Thesis (Ph.D.) - Loughborough University of Technology, 1992.

Statementby Wai-Han Cheung.
ID Numbers
Open LibraryOL21516640M

Coordinator: Prof. Fiorella Meneghetti. Research Collaborators: Dr. Elena Pini, Dr. Matteo Mori (Dottorando di ricerca). X-Ray Crystallographic Laboratory. The X-Ray Crystallographic Laboratory located at the Department of Pharmaceutical Sciences aims at understanding the structure, function and target interactions of important novel pharmaceutical derivatives at a molecular level. Structural biochemistry is a branch of the life sciences, specially biochemistry, that combines biology, physics, and chemistry to study living organisms and to summarize some mutual physicochemical underlying principles that all forms of life share.

Oestrogens used in the pharmaceutical industry can generally be classified as natural or synthetic and as steroidal or non-steroidal. All steroidal oestrogens, both natural (e.g., oestrone) and synthetic (e.g., ethynyloestradiol and moestranol) have a typical multi-ring structure, as depicted in figure Diethylstilboestrol (DES) and. Redox-cycling and intercalating properties of novel mixed copper(II) complexes with non-steroidal anti-inflammatory drugs tolfenamic, mefenamic and flufenamic acids and phenanthroline functionality: Structure, SOD-mimetic activity, interaction with albumin, DNA damage study and anticancer activity.

Topological inhibitors (so-called “topological drugs”) are rigid three-dimensional molecules of inorganic, organic and hybrid compounds (as guests) that form multicentered supramolecular interactions in vacant cavities of protein macromolecules and their complexes (as hosts) [clarification needed].Extensive surface and very diverse geometry make cage compounds with an encapsulated metal. Stanford Libraries' official online search tool for books, media, journals, databases, government documents and more.


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Novel steroidal metal complexes with potential pharmaceutical applications by Wai-Han Cheung Download PDF EPUB FB2

Novel steroidal metal complexes with potential pharmaceutical applications Author: A study to develop novel lipophilic metal ion complexes based on dihydrocholesterol was undertaken. Steroid ligands functionalised at the 2- and 3- positions were synthesized as possible bidentate ligands for complexation of metal ions.

Condensation of 5α Author: Wai-Han Cheung. Novel steroidal metal complexes with potential pharmaceutical applications. (Thesis) Cheung W. Publisher: Loughborough University of Technology [] Metadata Source: The British Library Type: Thesis. Abstract. Highlight Terms No biological terms identified.

Topics: 06B - Bioengineering, biomedical engineering, biotechnology, biochemical engineering, 06O - Pharmacology, pharmacy, pharmaceutical chemistry, 07C - Organic chemistry, Novel steroidal metal complexes with potential pharmaceutical applications [ Drug delivery systems, Lipophilicty]Author: W Cheung.

The proposed curative properties of Cu-based non-steroidal anti-inflammatory drugs (NSAIDs) have led to the development of numerous Cu(II) complexes of NSAIDs with enhanced anti-inflammatory.

The results suggested the promising application of this series of estrogen-derived metal complexes as a novel type of targeting agents for estrogen receptors. As shown in Scheme 2, compounds 1 and 2 were conveniently prepared from squaric acid and 1,2-cyclohexanediamine respectively with moderate yield (Scheme 2 A and B).

17 These two Cited by: 6. Gold-based anticancer agents have gained the widespread attention of medicinal inorganic chemists due to their unique chemical properties and strong a. Synthesis and spectroscopic characterizations of noble metal complexes (gold, silver, platinum) in the presence of selenium, and their biological applications as antibacterial, antifungal, and anticancer.

Research on Chemical Intermediates41, DOI: /s In metal-peptide interactions, cations form stable complexes through bonds with coordinating groups as side chains of amino acids. These compounds, among other things, exert a wide variety of antimicrobial activities through structural changes of peptides upon metal binding and redox chemistry.

They exhibit different mechanisms of action (MOA), including the modification of DNA/RNA, protein. We have prepared a series of bis-bidentate complexes of rhenium that mimic the size, shape, and peripheral functionality of steroidal androgens.

In a model system, we used 2D NMR and X-ray crystallographic analysis to show that adjacent N-methyl and oxo substitutents adopt an anti configuration during the coordination reaction. We have synthesized a bis-bidentate oxorhenium(V) complex whose.

4-(1H-1,2,4-Triazolylmethyl)aniline was prepared by known method reported in literature [] and was characterised by spectroscopic laldehyde was purchased from Merck Chemicals.

4-(1H-1,2,4-Triazolylmethyl)aniline ( g, mole) was taken in 10 mL ethanol, salicylaldehyde ( g, mole) was added, and solution was heated to reflux in water for about 2 hours.

The ability of Zn(II) and Cu(II) metal complexes of non-steroidal anti-inflammatory drugs (NSAIDs) to inhibit acute arterial inflammation in vivo has been studied. Non-steroidal anti-inflammatory drugs (NSAIDs) are amongst the most commonly prescribed drugs in. Books at Amazon.

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Oxovanadium(IV) complexes with four different non-steroidal anti-inflammatory drugs have been synthesized. These complexes were characterized by different. Cobalt Complexes with Bioactive Ligands.

Bioactive small molecules that elicit therapeutic action in vivo, such as non-steroidal anti-inflammatory drugs (NSAIDs) [17–19], antibacterial agents [20,21], antiprotozoal agents [22,23], antifungal agents [24,25], and antihelmintic agents [], have been attached to cobalt complexes to improve or alter their therapeutic efficacy.

Herein, a new class of iridium(III)-based metal complexes with phosphine-imine (P^N) ligands are synthesized and complexes show high cytotoxicities against seven cancer cells in aneously, antitumor mechanism studies show that complex Ir3 induces apoptosis by depolarization of mitochondrial membrane potential, ROS overproduction and ROS-mediated DNA.

Cyclodextrins (CDs) are cyclic oligosaccharides of natural origin that were discovered more than years ago. The peculiar cone-like conformation of the sugar ring, expressing a lipophilic cavity and a hydrophilic external surface, allows these substances to spontaneously complex poorly soluble compounds in an aqueous environment.

For more than 50 years, these substances have found. The europium complex is part of the lanthanide fluorobenzoate class of compounds. 67,68 It has good luminescent properties which make it suitable for applications in cellular imaging, immunoassays and organic light-emitting diodes.

69–71 The zinc complex 26 is related to a class of macrocyclic metal complexes recently shown to have promising. Keywords:Hydrazone, metal-complexes, anticancer activity, MTT assay, real-time monitoring, proliferative system.

Abstract: Background: Hydrazones, one of the important classes of organic molecules, are pharmaceutical agents comprising –CO-NH-N=CH- group in the structure therefore and exhibiting significant biological activity. Metal carbene complexes have made their way from organometallic curiosities to valuable reagents and catalysts.

They offer novel synthetic opportunities in carbon carbon bond formation based on either carbene-centered reactions or on metal-templated processes which makes them indispensable in modern synthetic methodology. The interaction of transition metal ions with biological molecules provides one of the most fascinating areas of coordination chemistry.

The application of this field to biomedical uses is dealt with in 5 chapters. Chapter 18 by N. Farrell, deals with the use of metal complexes as drugs and chemotherapeutic agents. Abstract: Sodium potassium pump (Na + /K + ATPase) is a validated pharmacological target for the treatment of congestive heart failure.

Recent data with inotropic drugs such as digoxin & digitoxin (digitalis) suggest a potent anti-cancer action of these drugs and promote Na + /K + ATPase as a novel therapeutic target in cancer.

However, digitalis have narrow therapeutic indices, are pro. In31 new chemical entities were introduced to the world pharmaceutical market and 2, molecules were in phase I or II of clinical development majority of .Metal carbene complexes have made their way from organometallic curiosities to valuable reagents and catalysts.

They offer novel synthetic opportunities in carbon-carbon bond formation based on either carbene-centered reactions or on metal-templated processes which makes them indispensable in modern synthetic methodology.